Update your password regularly to keep your account safe.
Skip brand navigation
Where are you going?
City, airport, address, attraction, or hotel
Use HHonors Points
Use flexible dates
AAA rate *
AARP rate *
CARP rate *
Government / Military rates *
* ID required at check-in
close tab panel
Find where we are located
View the Maps & Directions Page
Skip secondary navigation
Find our hotel in Mehlville, MO area just off of I-55, south of St. Louis.From North or South (Coming From Downtown St. Louis) on Interstate 55, Take the Butler Hill Road Exit (Exit #195). Head East on Butler Hill Road About 1/10 Mile and turn right on MidAmerica Plaza Drive. Hampton Inn & Suites St. Louis South is located on the southeast corner of I-55 and Butler Hill Road.From Interstate 70 West, Take I-64 E via Exit 210A toward Chesterfield for 27 Miles. Take 270 South (Exit 25) for 12 Miles to Interstate 55 South. Take the Butler Hill Road Exit (Exit #195). Head East on Butler Hill Road about 1/10 mile and turn right on MidAmerica Plaza Drive. Hampton Inn & Suites St. Louis South is located on the corner of I-55 and Butler Hill Road.
This content will open in a overlay
Friendly service, clean rooms, comfortable surroundings, every time. If you're not satisfied, we don't expect you to pay. That's our commitment & your guarantee. That's 100% Hampton.
Our 100% Hampton Guarantee® is boldly etched on our front desk so that it is constantly visible to our employees and our guests. Our guarantee epitomizes the pride we take in our brand, our hotels and our service to you, our guest. We'll do whatever it takes to make our guests feel welcome, relaxed and completely comfortable.