Update your password regularly to keep your account safe.
Skip brand navigation
Where are you going?
City, airport, address, attraction, or hotel
Use HHonors Points
Use flexible dates
AAA rate *
AARP rate *
CARP rate *
Government / Military rates *
* ID required at check-in
close tab panel
Find where we are located
View the Maps & Directions Page
This content will open in a overlay
*Best Price Guarantee
Assures you receive the best price when you book directly with us. If you find a lower publicly available price anywhere else, we will match that price plus give you an additional US $50 back, subject to ourTerms and Conditions.
Skip secondary navigation
Find a cozy hotel in historic Missouri at Hampton Inn Cape Girardeau. Just off the I-55, you’ll find the Hampton Inn Cape Girardeau hotel at the heart of this charming city. With 39 historic sites on the National Register, Cape Girardeau was once the busiest steamboat port on the Mississippi River. These days, you can watch riverboats dock from Riverfront Park, visit the Fort D historic site and enjoy browsing the many antique stores of well-preserved downtown Cape Girardeau, MO.
Relax in a comfortable guest room featuring a clean and fresh Hampton beds®. Accessible rooms are designed with generous door and furniture clearances for easy movement. Stay connected in your hotel room in Cape Girardeau, MO with free high-speed internet access. Maintain your exercise routine with the cardio equipment and weights in our fitness center during your stay at our Cape Girardeau hotel.
Start your day right with a Hampton free hot breakfast – choose fresh waffles, hot oatmeal, and fresh fruit. If you’re in a rush on weekdays, we’ll give you a Hampton On the Run™ breakfast bag to go. Ask our local experts – the friendly Hampton Inn Cape Girardeau hotel team – for Cape Girardeau, MO restaurant recommendations.