Update your password regularly to keep your account safe.
Skip brand navigation
Where are you going?
City, airport, address, attraction, or hotel
Use HHonors Points
Use flexible dates
AAA rate *
AARP rate *
CARP rate *
Government / Military rates *
* ID required at check-in
close tab panel
Find where we are located
View the Maps & Directions Page
This content will open in a overlay
Your membership can save you up to 10% off our Best Available Rate.
View Offer Details
Get the best price when you book directly with us.
If you find a lower publicly available price anywhere else, we will match that price and give you an additional US $50 back.
Skip secondary navigation
Experience charming and historic St. Charles, MO during your stay at the Hampton Inn St. Louis/St. Charles hotel, 25 miles from St. Louis, Missouri. Stroll the brick-lined streets, lunch in a Victorian house or browse for antiques and unique gifts in a Main Street boutique. Celebrate frontier heritage at the site where explorers Lewis and Clark met before their expedition. Dine at Lewis & Clark, an American restaurant and public house located in an historic three-story home with outdoor patio overlooking the Missouri River and Main Street.
Enjoy classic American fare at Miss Aimee B's Tea Room before shopping at The Upstairs Marketplace. Tour Missouri wineries including Balducci Vineyards, Little Hills Winery, and Yellow Farmhouse Winery just minutes from the St. Charles, MO hotel. Our 122-room hotel is less than two miles from Lindenwood University. Visit the famous Gateway Arch or the St. Louis Museum of Art located in an historic Beaux-Art building.
Whether you’re staying at our St. Charles, Missouri hotel on business or planning a weekend getaway in charming historic St. Charles, enjoy comfortable guest rooms with free high-speed internet access and 32-inch flat-screen TVs during your stay. Finish a presentation for tomorrow's meeting at our large work desk. Our lap desk makes it convenient to check your emails while you relax in your Hampton clean and fresh bed®.