Skip brand navigation
Where are you going?
City, airport, address, attraction, or hotel
Use HHonors Points
Use flexible dates
AAA rate *
AARP rate *
CARP rate *
Government / Military rates *
* ID required at check-in
close tab panel
Find where we are located
View the Maps & Directions Page
This content will open in a overlay
The HHonors Weekend delivers. Book your stay at our Hampton hotel & enjoy Double Points.
View Offer Details
Skip secondary navigation
Stay at our Hampton Inn Buffalo South/I-90 hotel, located immediately off Interstate 90 in West Seneca, New York. Our suburban hotel in West Seneca, NY is situated 10 minutes from downtown Buffalo.
Tour Our Lady of Victory Basilica, admire the architecture of homes designed by Frank Lloyd Wright, and appreciate the flora at the Buffalo Botanical Gardens. Shop the Galleria Mall or McKinley Mall. Catch a Buffalo Bills’ football game at Ralph Wilson Stadium, just 10 minutes from the hotel, or taking a boat tour of Niagara Falls, about 30 minutes away. Take advantage of our location near Orchard Park, NY, to make connections with companies in several business parks.
Start your sightseeing or work day right with Hampton’s free hot breakfast daily. Ask about restaurants that deliver food to our hotel or dine at Irish pubs and eateries in South Buffalo.
Relax and refresh after work or leisure activities in a comfortable king- or queen-sized bed in one of our 106 guest rooms or suites. Each room is equipped with free WiFi access and a 32-inch flat-screen television with a premium movie channel and on-demand video games. Plan tomorrow’s activities while reclining on your bed using our convenient lap desk. Ask about our guest rooms with sofa beds, microwave ovens and mini-refrigerators. Upgrade to a suite to enjoy a whirlpool spa and a kitchenette.
Enjoy the comforts of home and friendly service at our hotel in West Seneca, NY.