Skip brand navigation
Where are you going?
City, airport, address, attraction, or hotel
Use HHonors Points
Use flexible dates
AAA rate *
AARP rate *
CARP rate *
Government / Military rates *
* ID required at check-in
close tab panel
Find where we are located
View the Maps & Directions Page
This content will open in a overlay
Active & retired military and their families enjoy exclusive savings of up to 15% off at Hampton.
View Offer Details
Skip secondary navigation
The Hampton Inn hotel in Santee, SC is located near Lake Marion and five golf courses. Take in the beauty of Santee State Park, commune with nature at the Santee National Wildlife Refuge or go fishing, boating, or swimming on Lake Marion – it's all just outside the door at our Santee hotel. Captain’s Quarters is within walking distance, and it's a short drive to Clark’s Restaurant - both are locals’ favorites. Golf any time at the Lake Marion Country Club, Santee National, Santee Resort and several others. Our hotel in Santee also puts you within easy reach of historical sites such as Eutaw Springs Battlefield.
Discover what makes Hampton Inn Santee-I-95 unique among Santee, SC hotels. Unwind in a spacious guest room and enjoy modern comforts to help you feel at home. Stay connected with free internet access and work in comfort with a practical lap desk. Enjoy our King rooms’ sofa bed and cocktail tables, allowing you to stretch out and fully relax. Take advantage of our double queen bedrooms, which offer a sitting area. Enjoy great value during your stay in our outdoor swimming pool and gym. Catch up with work in the business center and host meetings for up to 30 guests in our 576 sq. ft. multi-function event room.
The hotel is able to accommodate boat trailers and RVs in our extended parking lot, with power connections available to guests.
Circle of Excellence
All Hampton guests age 65+ can save up to 10% off our Best Available Rate when booking online.
View Package Details