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Hotel Information

3:00 pm
11:00 am
$250 USD fee will be assessed for smoking in a non-smoking room. The smokers oasis is located northwest of the front entrance of the hotel.
Self parking: (Free Parking)
Valet: Not Available
Service animals allowed: Yes
Pets allowed: No

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Hampton Inn & Suites St. Louis/South I-55

4200 MidAmerica Lane, Saint Louis, Missouri, 63129, USA TEL: +1-314-894-1900 FAX: +1-314-894-0063
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At a Glance

old world charm meets Midwest hospitality.

Experience the delightful mix of Old World charm and Midwest hospitality in the vibrant city of St. Louis when you stay at our Hampton Inn & Suites St Louis/South I-55 hotel. Be greeted by an incredibly attentive and accommodating staff that rivals many hotels. Enjoy easy access to downtown to visit the city’s signature Gateway Arch. Ride the tram to the top, where 32 windows offer spectacular views of this ‘Gateway to the West’ city.

Located near downtown St. Louis, our hotel is convenient to many attractions and businesses. Explore museums or visit the St. Louis Zoo. Attend a baseball game at Busch Stadium, home of the St. Louis Cardinals. Tour the famous Anheuser-Busch Brewery. Savor the best of Italian food in the Hill neighborhood, or visit the Soulard neighborhood for jazz and blues clubs, as well as the Soulard Farmer’s Market.

Retreat to one of our 92 St. Louis hotel rooms to rest in a clean and fresh Hampton bed®. Join us each morning for Hampton’s free hot breakfast. Even if you're in a rush, simply grab one of our free Hampton On the Run® Breakfast Bags, available Monday through Friday, for a quick, healthy meal to go. You'll also find great business services, free WiFi, and recreational facilities for a truly enjoyable stay at our St. Louis hotel.

About The Hotel

Hotel Facts

  • Near downtown St. Louis, convenient to businesses and local attractions
  • Convenient to the Anheuser Busch Brewery
  • 92 non-smoking guest rooms and suites
  • Accessible rooms
  • Executive meeting room with a ceiling-mounted projector, in-room sound system and more

Rooms & Suites

Included in Every Stay

  • Free hot breakfast
  • Clean and fresh Hampton bed®
  • Free high-speed internet access in every room
  • Gym/fitness center Use


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100% Hampton
100% Hampton

100% Hampton Guarantee®

Making you happy makes us happy. So, if we can make your stay better, talk to any member of our team, and we'll make sure you're 100% happy. GUARANTEED.™