Hampton by Hilton

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Hotel Information

3:00 pm
11:00 am
A fee of up to 250 USD will be assessed for smoking in a non-smoking room. Please ask the Front Desk for locations of designated outdoor smoking areas.
Self parking: (Free On-site Parking)
Valet: Not Available
Service animals allowed: Yes
Pets allowed: No

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Hampton Inn Sikeston

1240 Commerce Drive, Sikeston, Missouri, 63801, USA TEL: +1-573-621-4100 FAX: +1-573-621-4101
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At a Glance

new Sikeston hotel minutes from historic downtown.

Settle in for a relaxing stay at the Sikeston’s newest hotel. Our Hampton Inn Sikeston hotel is located off Highway 60 and Interstate 55, just minutes from historic downtown and within walking distance to many shops and restaurants.

Settle in for a relaxing stay in one of our modern guest rooms. Enjoy the convenience of a mini-refrigerator, microwave, free WiFi, coffeemaker, 42-inch flat-screen TV with premium cable channels and work desk with ergonomic chair. Upgrade to a studio suite for extra space and a separate seating area. Start each day with our free hot breakfast or, if you’re in a hurry, grab one of Hampton’s On the Run™ Breakfast Bags, available Monday through Friday. Stop by our Treats Shop any time of day or night for a quick snack or beverage. Stay in shape with a workout in our 24-hour fitness center or take a dip in our indoor heated pool. Plan a meeting in our 700 sq. ft. of meeting space fully equipped with A/V equipment.

About the Hotel

Hotel Facts

  • Located off Highway 60 and Interstate 55, minutes from historic downtown
  • Within walking distance to many restaurants and shops
  • 24-hour TREATS Shop and business center
  • Mini-refrigerator and microwave in each room
  • Indoor heated pool
  • 700 sq. ft. of Sikeston meeting space

Rooms & Suites

Included in Every Stay

  • Free Hot breakfast
  • Clean and comfy bed
  • Free WiFi in every room
  • Gym/fitness center use


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100% Hampton
100% Hampton

100% Hampton Guarantee®

Making you happy makes us happy. So, if we can make your stay better, talk to any member of our team, and we'll make sure you're 100% happy. GUARANTEED.™